|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
The role of microbial low-molecular-weight autoregulatory factors (alkylhydroxybenzenes) in resistance of microorganisms to radiation and heat shockстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Дата последнего поиска статьи во внешних источниках: 18 декабря 2013 г.
- Авторы: El-Registan G.I., Mulyukin A.L., Nikolaev Y.A., Stepanenko I.Y., Kozlova A.N., Martirosova E.I., Shanenko E.F., Strakhovskaya M.G., Revina A.A.
- Сборник: Space Life Sciences: Aircraft and Space Radiation Environment
- Серия: Advances in Space Research
- Том: 36
- Год издания: 2005
- Место издания: Comm Space Res Paris, FRANCE
- Первая страница: 1718
- Последняя страница: 1728
- Аннотация: Low-molecular-weight cell-to-cell communication factors are produced by various pro- and eukaryotes and involved in autoregulation of the growth and development of microbial cultures. As for some bacterial and yeast species, these factors were identified as isomers and homologues of alkylhydroxybenzenes (AHB). Depending on the concentration, they participate in controlling the transition to stationary phase, entering the resting state, and stress resistance of vegetative cells to gamma-irradiation, photooxidation (singlet oxygen), and heat shock. Chemical analogues of microbial AHB protected microbial cultures from stressful situations and exerted (1) the stabilizing activity toward macromolecules and (2) the ability to scavenge active oxygen species. The stabilizing effect of AHBs resulted from their complex formation with protected macromolecules due to intermolecular hydrogen bonds, hydrophobic and electrostatic interactions and was demonstrated on models of individual enzymes (trypsin). Particularly, AHBs protected the yeast from the action of (a) active oxygen species formed during gamma-irradiation (500 Gy, 1.96 Gy/s) or (b) singlet oxygen generated in cells photosensitized by chlorin e(6) (10 mu g/L). It is important that microbial AHBs were not species-specific and defended cultured microbial and animal cells from the action of organic toxicants. The use of AHBs as protectants and adaptogens is discussed as well as perspectives of further investigations. (c) 2005 COSPAR. Published by Elsevier Ltd. All rights reserved.
- Добавил в систему: Страховская Марина Глебовна