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An Interactive Method of Anatomical Segmentation and Gene Expression Estimation for an Experimental Mouse Brain Sliceстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Дата последнего поиска статьи во внешних источниках: 19 июля 2013 г.
- Авторы: Osokin Anton, Vetrov Dmitry, Lebedev Alexey, Galatenko Vladimir, Kropotov Dmitry, Anokhin Konstantin
- Сборник: Computational Intelligence Methods for Bioinformatics and Biostatistics
- Серия: Lecture Notes in Computer Science
- Том: 6685
- Год издания: 2011
- Издательство: SPRINGER-VERLAG BERLIN
- Местоположение издательства: HEIDELBERGER PLATZ 3, BERLIN, GERMANY,D-14197
- Первая страница: 86
- Последняя страница: 97
- DOI: 10.1007/978-3-642-21946-7_7
- Аннотация: We consider the problem of statistical analysis of gene expression in a mouse brain during cognitive processes. In particular we focus on the problems of anatomical segmentation of a histological brain slice and estimation of slice's gene expression level. The first problem is solved by interactive registration of an experimental brain slice into 3D brain model constructed using Allen Brain Atlas. The second problem is solved by special image filtering and further smart resolution reduction. We also describe the procedure of non-linear correction of atlas slices which improves the quality of the 3D-model significantly.
- Добавил в систему: Осокин Антон Александрович