Structural characterization of [1,4]diazepino[6,5-b]indoles by powder diffractionстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:As part of a systematic structural study of potentially pharmacologically active [1,4] diazepino[6,5-b] indoles, the crystal structures of nine compounds have been determined from laboratory powder diffraction data. The investigated compounds are: 2-oxo-1-(4-nitrophenyl)- 1,2,3,6-tetrahydro[ 1,4] diazepino[ 6,5-b] indole-4-oxide, C17H12N4O4 (1a); 2-oxo- 1-phenyl-1,2,3,6-tetrahydro[1,4] diazepino[6,5-b] indole-4-oxide, C17H13N3O2 (1b); 2-oxo-1-(4-ethoxyphenyl)-1,2,3,6-tetrahydro[ 1,4] diazepino[6,5-b] indole-4-oxide, C19H17N3O3( 1c); 2-oxo- 1-(4-chlorophenyl)- 1,2,3,6- tetrahydro[ 1,4] diazepino[ 6,5-b] indole-4-oxide, C17H12N3O2Cl (1d); 2-oxo-1-(4-cyanophenyl)- 1,2,3,6-tetrahydro[1,4] diazepino[6,5-b] indole-4-oxide, C18H12N4O2 (1e); 6-methyl-2-oxo-1-phenyl-1,2,3,6-tetrahydro[ 1,4] diazepino[6,5-b] indole-4-oxide, C18H15N3O2 (1f); 2-formyl-3-[N'-(omega-chloracetyl)- N'-(4-nitrophenyl)] aminoindole, C17H12N3O4Cl (2a); 2-formyl-3-[N'-(omega-chloracetyl)N'-( 4-nitrophenyl)] aminoindole solvate with toluene (2: 1), C17H12N3O4Cl center dot 0.5C(7)H(8) (2as); 2-formyl-3-[N'-(omega-chloracetyl)N'-( 4-cyanophenyl)] aminoindole, C18H12N3O2Cl (2e). Compounds ( 1a) -( 1f) crystallize in non-centrosymmetric triclinic, monoclinic and orthorhombic space groups. The three-dimensional structures of ( 1a) -( 1e) demonstrate identical intermolecular NH( indole) center dot center dot center dot O<--N hydrogen bonds, which form linear chains of connected molecules. A comparison of the crystal structures ( 2a), ( 2e) and ( 2as) shows that the solvent used in the re-crystallization of ( 2a) and ( 2e), which are intermediates in the synthesis of ( 1a) and ( 1e), affects the intermolecular hydrogen-bond formation and, as a result, leads to essentially different yields of the goal products.