New approach to the functionalization of delta-carboline derivativesстатья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:The possibility of transformation of 3-cyano-1-p-nitrophenyl-delta-carbolin-2-one into 2-amino-3-cyano-1-p-nitrophenyl-1H-pyrido[3,2-b]indole derivatives and 2-imino-3-cyanol-p-nitrophenyl-5H-pyrido[3,2-b]indole derivatives (delta-carbolines) is demonstrated. Methylation of 1-p-nitrophenyl-2-piperidino-1H-delta-carboline followed by treatment with acetone in an alkaline medium yields 4-acetonyl-5-methyl-1,4-dihydro-5H-pyrido[3,2-b]indole derivative. The rearrangement of 2-arylimino-3-cyano-1-p-nitrophenyl-5H-pyrido[3,2-b]indoles into 2-(aryl)nitrophenylamino-3-cyano-5H-pyrido[3.2-b]indoles was accomplished on heating above the melting point or on treatment with potassium tert-butoxide. The structures of the resulting compounds were proved by (1)H and (13)C NMR spectroscopy and X-ray diffraction analysis.