Reaction of ephedrine hydrochloride with sodium crosscarmellose and its account in the analysis of ephedrine-containing preparationsстатья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:It is shown by HPLC and Fourier-transform IR spectrometry that ephedrine hydrochloride (EH) reacts with an auxiliary pharmaceutical substance, sodium crosscarmellose, in aqueous-organic solutions and in dry mixtures. This process may lead to the underestimation of the results of determining EH in the analysis of preparations containing these components. A probable mechanism of the reaction of EH with sodium cross-carmellose is considered, and possible techniques for eliminating its interfering effect are proposed.