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[Generation of blood anticoagulant and fibrinolytic activity after intravenous administration of protein C-a in rats]статья
Дата последнего поиска статьи во внешних источниках: 23 января 2020 г.
- Авторы: Kogan A.E., Strukova S.M.
- Журнал: Biulleten' eksperimental'no∎ biologii i meditsiny
- Том: 107
- Номер: 1
- Год издания: 1989
- Издательство: Administrativnoia Zdaniia Minzdrava Sssr
- Местоположение издательства: Moskva, Russia (Federation)
- Первая страница: 3
- Последняя страница: 5
- Аннотация: Protein C–vitamin K-dependent protein of the blood coagulation system possessing anticoagulant and fibrinolytic activities was under investigation. Activated partial thromboplastin time was shown to prolong to 214 +/- 8.9% from the first minute after intravenous administration of 0.51 mg per rat bovine protein Ca. After 5 minutes the activity of plasminogen activators increased to 339 +/- 52.8%. Both effects gradually diminished and came back to the starting level within 60-90 minutes. The factor V activity reduced two-fold and didn’t return to basal level. We propose that protein Ca reveals its enzymatic activity within first minutes after administration and is blocked then with its inhibitor.
- Добавил в систему: Струкова Светлана Михайловна