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[The compensatory-adaptive mechanisms in nitrite-induced hypoxia in rats]статья
Дата последнего поиска статьи во внешних источниках: 23 января 2020 г.
- Авторы: Reutov V.P., Sorokina E.G., Pinelis V.G., Korshunova T.S., Rodionov A.A., Koshelev V.B., Strukova S.M., Kaiushin L.P., Braquet P., Komissarova L.K.h
- Журнал: Biulleten' eksperimental'no∎ biologii i meditsiny
- Том: 116
- Номер: 11
- Год издания: 1993
- Издательство: Administrativnoia Zdaniia Minzdrava Sssr
- Местоположение издательства: Moskva, Russia (Federation)
- Первая страница: 506
- Последняя страница: 8
- Аннотация: Concentration of blood proteins, alpha-amino nitrogen, cGMP and endothelin-1,2 was studied in rat’s blood at nitric hypoxia. The injection of NaNO2 (5 mg/100 g body weight) was followed by decrease in total protein, albumin and hemoglobin content and by sharp increase in methemoglobin and Hb-NO complexes concentration in rat’s blood. Simultaneously, the elevation of free amino acids and peptides with m.w. 2500 D in blood was discovered. One of these peptides was the endothelin-1,2, whose concentration increased twice in plasma at nitric hypoxia. The increase in endothelin and cGMP concentrations is mostly linked with activation of compensative mechanisms, arising as a response to high concentrations of nitro compounds and NO in rats.
- Добавил в систему: Струкова Светлана Михайловна