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Synthesis of d-(+)-camphor-based N-acylhydrazones and their antiviral activityстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 апреля 2019 г.
- Авторы: Kovaleva K.S., Zubkov F.I., Bormotov N.I., Novikov R.A., Dorovatovskii P.V., Khrustalev V.N., Gatilov Y.V., Zarubaev V.V., Yarovaya O.I., Shishkina L.N., Salakhutdinov N.F.
- Журнал: MedChemComm
- Том: 9
- Номер: 12
- Год издания: 2018
- Издательство: Royal Society of Chemistry
- Местоположение издательства: United Kingdom
- Первая страница: 2072
- Последняя страница: 2082
- DOI: 10.1039/C8MD00442K
- Аннотация: The design and synthesis of a series of novel D-(+)-camphor N-acylhydrazones exhibiting inhibitory activity against vaccinia and influenza viruses are presented. An easy pathway to camphor-based N-acylhydrazones containing in their structure aliphatic, aromatic, and heterocyclic pharmacophore scaffolds has been developed. The conformation and configuration of the synthesized hydrazones were thoroughly characterized by a complete set of spectral characterization techniques, including 2D NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. In vitro screening for activity against vaccinia virus (VV) and influenza H1N1 virus was carried out for the obtained compounds. It was revealed that the derived N-acylhydrazones exhibited significant antiviral activity with a selectivity index >280 against VV for the most promising compound.
- Добавил в систему: Зубков Фёдор Иванович