|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
LINC00116 codes for a mitochondrial peptide linking respiration and lipid metabolismстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 6 мая 2019 г.
- Авторы: Chugunova Anastasia, Loseva Elizaveta, Mazin Pavel, Mitina Aleksandra, Navalayeu Tsimafei, Bilan Dmitry, Vishnyakova Polina, Marey Maria, Golovina Anna, Serebryakova Marina, Pletnev Philipp, Rubtsova Maria, Mair Waltraud, Vanyushkina Anna, Khaitovich Philipp, Belousov Vsevolod, Vysokikh Mikhail, Sergiev Petr, Dontsova Olga
- Журнал: Proceedings of the National Academy of Sciences of the United States of America
- Том: 116
- Номер: 11
- Год издания: 2019
- Издательство: National Academy of Sciences
- Местоположение издательства: United States
- Первая страница: 4940
- Последняя страница: 4945
- DOI: 10.1073/pnas.1809105116
- Аннотация: Genes coding for small peptides have been frequently misannotated as long noncoding RNA (lncRNA) genes. Here we have demonstrated that one such transcript is translated into a 56-amino-acid-long peptide conserved in chordates, corroborating the work published while this manuscript was under review. The Mtln peptide could be detected in mitochondria of mouse cell lines and tissues. In line with its mitochondrial localization, lack of the Mtln decreases the activity of mitochondrial respiratory chain complex I. Unlike the integral components and assembly factors of NADH:ubiquinone oxidoreductase, Mtln does not alter its enzymatic activity directly. Interaction of Mtln with NADH-dependent cytochrome b5 reductase stimulates complex I functioning most likely by providing a favorable lipid composition of the membrane. Study of Mtln illuminates the importance of small peptides, whose genes might frequently be misannotated as lncRNAs, for the control of vitally important cellular processes.
- Добавил в систему: Серебрякова Марина Васильевна