Ca-release channels (ryanodine receptors) of sarcoplasmic reticulum: Structure and properties. A reviewстатья
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Дата последнего поиска статьи во внешних источниках: 19 июля 2013 г.
Аннотация:Recent data on characteristics of the structure, function, and regulation of sarcoplasmic reticulum Ca-release channels (ryanodine receptors) From various types of muscles are summarized. The history of identification and purification of Ca-release ch;channels, the properties of isoforms expressed in various tissues, their electric characteristics, and regulation bl endogenous and exogenous compounds are described. The phosphorylation of Ca-release channels by protein kinases and their interaction with various intracellular regulatory proteins are discussed. The proposed mechanisms of excitation-contraction coupling and the role of the Ca-release channels in this process are analyzed.