MECHANISM OF THERMAL UNCOUPLING OF THE SARCOPLASMIC-RETICULUM CA2+-PUMP - CHANGE IN FUNCTIONAL-PROPERTIES AND STRUCTURAL STATE OF THE ENZYME MOLECULEстатья
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Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 мая 2015 г.
Местоположение издательства:Road Town, United Kingdom
Первая страница:934
Последняя страница:942
Аннотация:The effect of short thermal treatment resulting in uncoupling of hydrolytic and transport functions of skeletal muscle sarcoplasmic reticulum Ca2+-ATPase on the conformational state of the enzyme and the physicochemical parameters of the membrane lipid bilayer was investigated It was found that the main reason for the decrease in efficiency of the Ca2+-pump is the increase in membrane permeability for Ca2+. No change in Ca2+-ATPase hydrophilic domain conformation was found after thermal treatment. However, thermal treatment restricts the accessibility of the transmembrane hydrophobic domain of the enzyme to several compounds, decreases microviscosity of the lipid bilayer, and modifies protein-lipid and protein-protein interactions in the membrane.