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Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cellsстатья
Информация о цитировании статьи получена из
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Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 29 мая 2019 г.
- Авторы: Peunova N., Enikolopov G.
- Журнал: Nature
- Том: 375
- Номер: 6526
- Год издания: 1995
- Издательство: Nature Publishing Group
- Местоположение издательства: United Kingdom
- Первая страница: 68
- Последняя страница: 73
- DOI: 10.1038/375068a0
- Аннотация: Arrest of cell division is a prerequisite for cells to enter a programof terminal differentiation. Mitogenesis and cytostasis of neuronalcell precursors can be induced by the same or by different growthor trophic factors0-9. Response of PC12 cells to nerve growthfactor (NGF) involves a proliferative phase that is followed bygrowth arrest and differentiation. Here we present evidence thatthe cytostatic effect of NGF is mediated by nitric oxide (NO), asecond messenger molecule with both para- and autocrine proper-ties that can diffuse freely and act within a restricted volume . We show that NGF induces different forms of nitric oxide synthase (NOS) in neuronal cells, that nitric oxide (NO) acts as a cytostaticagent in these cells, that inhibition of NOS leads to reversal ofNGF-induced cytostasis and thereby prevents full differentiation, and that capacity of a mutant cell line to differentiate can berescued by exogenous NO. We suggest that induction of NOS isan important step in the commitment of neuronal precursors andthat IOS serves as a growth arrest gene, initiating the switch tocytostasis during differentiation. © 1995, Nature Publishing Group. All Rights Reserved.
- Добавил в систему: Ениколопов Григорий Николаевич