Neonatal hyperthyroidism increases anticontractile influence of NO in rat arteriesстатьяТезисы
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Дата последнего поиска статьи во внешних источниках: 11 ноября 2019 г.
Аннотация:Endothelium synthesizes NO that can reduce arterial contractile responses thereby exhibiting anticontractile influence. This influence is highly pronounced in 2-week-old rats compared to adults. Recently we have shown that thyroid deficiency during early stages of ontogenesis decreases the anticontractile effect of NO in arteries of 2-week-old rats. However, the impact of thyroid hormones excess on the anticontractile effect of NO in young arteries has not been studied yet. Our results demonstrate that neonatal hyperthyroidism increases anticontractile influence of NO in arteries of 2-week-old rats that is followed by compensatory reduction of arterial NO-responsiveness. The study was supported by the Russian Science Foundation (grant N14-15-00704).