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Proteins Tightly Bound to DNA: New Data and Old Problemsстатья
Информация о цитировании статьи получена из
Scopus,
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 мая 2016 г.
- Авторы: Sjakste N., Bagdoniene L., Gutcaits A., Labeikyte D., Bielskene K., Trapina I., Muiznieks I., VASSETZKY Y., Sjakste T.
- Журнал: Biochemistry (Moscow)
- Том: 75
- Номер: 10
- Год издания: 2010
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 1240
- Последняя страница: 1251
- DOI: 10.1134/S0006297910100056
- Аннотация: Proteins tightly bound to DNA (TBP) comprise a group of proteins that remain bound to DNA after usual deproteinization procedures such as salting out and treatment with phenol or chloroform. TBP bind to DNA by covalent phosphotriester and noncovalent ionic and hydrogen bonds. Some TBP are conservative, and they are usually covalently bound to DNA. However, the TBP composition is very diverse and significantly different in different tissues and in different organisms. TBP include transcription factors, enzymes of the ubiquitin-proteasome system, phosphatases, protein kinases, serpins, and proteins of retrotransposons. Their distribution within the genome is nonrandom. However, the DNA primary structure or DNA curvatures do not define the affinity of TBP to DNA. But there are repetitive DNA sequences with which TBP interact more often. The TBP distribution within genes and chromosomes depends on a cell’s physiological state, differentiation type, and stage of organism development. TBP do not interact with DNA in the sites of its association with nuclear matrix and most likely they are not components of the latter. Key words proteins tightly bound to DNA nuclear matrix repetitive DNA sequences serpins phosphatases transcription factors differentiation
- Добавил в систему: Васецкий Егор Сергеевич