The Structure of NO-Mediated Dilatation of Pulmonary Arteries Depends on NO Availabilityстатья
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Дата последнего поиска статьи во внешних источниках: 15 августа 2019 г.
Аннотация:NO-mediated vasodilatation can be realized via two pathways: dependent and independent
on soluble guanylate cyclase; the latter is implemented through NO interaction with ionic
channels. We evaluated the contribution of these pathways into NO-induced relaxation of
isolated pulmonary arteries in rats. In pulmonary arteries, in contrast to systemic vessels,
soluble guanylate cyclase-independent mechanisms is more important, because it mediates
relaxation in response to low concentrations of NO donor. The role of soluble guanylate
cyclase-dependent mechanisms in the mechanisms of vasodilatation increases with increasing
NO donor concentrations.