Intravenous administration of CoQ10 evokes increase in NO-mediated blood vessels relaxationстатьяТезисы
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Дата последнего поиска статьи во внешних источниках: 28 октября 2016 г.
Аннотация:Introduction: The presence of endothelial dysfunction is associated with an
increased mortality risk in patientswith chronic heart failure. Coenzyme Q10 (CoQ10)
is recommended for treatment of patients with congestive heart failure, but due to
its low bioavailability it is necessary long term administration in order to reach therapeutical
effect. One of the proposed mechanisms of beneficial effects of Coq10 is
improvement in the vasodilating NO-mediated function of endothelium.
Purpose: Investigation of the fast effects of CoQ10, administered intravenously, on
the NO-mediated vasorelaxation, evoked by acetylcholine. Methods. Male Wistar
rats (300-350g) were anaesthetized with chloralhydrate (400 mg/kg, ip) and placed
on a heated surgical pad at constant body temperature 37±0.5 ∘C. 3% water-based
solution of CoQ10 (30 mg/kg) or saline (0.9% NaCl, 1 mL/kg) were administered
intravenously via the femoral vein. 2 h after drugs administration the animals were
anaesthetized by chloralhydrate over dose (600 mg kg−1, ip) and decapitated. The
descending thoracic aorta was carefully excised and cut into ring segments 3 mm
in length and then transferred into 10-ml organ baths containing Krebs solution
bubbled with a mixture of 95% O2 and 5% CO2. The rings were precontracted
with 0.3 micromolar Phenylephine (PE), and after a steady-state tension had been reached,
increasing concentrations of ACh (0.001 micromolar - 30 micromolar) were cumulatively added to the organ bath.
Results: ACh elicited a concentration-dependent relaxation of rat aortic rings. The
maximum relaxation (E max, %) was obtained at a Ach concentration of 30 micromolar. In
the CoQ10-treated group the relaxant responses to ACh were markedly potentiated
when compared with the control (saline) group (94.2±2.0% vs 68.1±4.4%, respectively,
p<0.01). It was significant difference in pD2 (-lg EC50, ) values of the control
and treatment groups (5.79±0.29 vs 8.14±0.65, p<0.05).
Conclusion: 2h duration of CoQ10 (30 mg/kg) action is enough for improving the
vasodilating NO-mediated function of endothelium. This mechanism could be partially
responsible for positive effects of CoQ10 in congestive heart failure.