The effect of lamotrigine and carbamazepine on the development of audiogenic convulsive seizures in Krushinskii - Molodkina line of ratsстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 25 июля 2019 г.
Аннотация:The effect of Lamotrigine and Carbamazepine on the development and character of the epileptiform seizures after strong sonic stimulation were studied on Krushinskii - Molodkina line of rats. Both drugs manifested a dose-dependent increase in the latency of motor reaction. Lamotrigine administration in the dose range of 5-40 mg/kg, i.p., resulted in a moderate decrease in the seizure intensity preventing predominantly the tonic component of the sizure and failed to modify the character of convulsive reaction. Carbamazepine administered in doses of 7.5-30 mg/kg effectively prevented the epileptiform seizures. The "two-wave" motor reaction was observed in 15% of Carbamazepine -treated rats.