Influence of diphenin, valproate and pentobarbital on the development of epileptiform seizures in Krushinsky - Molodkina ratsстатья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:The anticonvulsant action of diphenin, sodium valproate, and pentobarbital was studied in Krushinsky - Molodkina (KM) rats subjected to audiogenic seizures. The anticonvulsant effects of the drugs were different and dose-dependent. Valproate in a dose of 120 mg/kg completely eliminated the tonic phase of seizures. Given in a dose of 300 mg/kg it in 50% of cases prevented from the development of the initial seizure stage of motor excitation. The peculiarity of the pentobarbital action consisted in its ability to change the character of motor excitation during sound stimulation from the one-wave reaction for the two-wave.