Deboronation of New Clarithromycin-Benzo[c][1,2]oxaborole Conjugates

Lapa, G.B.; Isakova, E.B.; Mirchink, E.B.; Preobrazhenskaya, M.N.

Авторы: Lapa G.B., Isakova E.B., Mirchink E.B., Preobrazhenskaya M.N.
Журнал: Anti-Infective Agents in Medicinal Chemistry
Том: 17
Номер: 2
Год издания: 2019
Издательство: Bentham Science Publishers
Местоположение издательства: Netherlands
Первая страница: 99
Последняя страница: 104
DOI: 10.2174/2211352517666181122130101
Аннотация: Abstract: Background: The conjugates of antibiotics are new molecules that might show new antibacterial spectrum and overcome resistance of insusceptible bacterial strains. Modification of known antibiotics like Clarithromycin with active fragments is laborious and proven method to overcome resistance of such strains.Methods: The conjugates of Clarithromycin and Benzo[c][1,2]oxaboroles were synthesized using long linkers to extend antimicrobial spectrum of this antibiotic.Results and Discussion: Unexpected intramolecular deboronation of these bioconjugated was found to occur when the linker contained two or more CH2-groups. Molecular modeling was used to understand the source of instability and show a possibility of intramolecular complex of carbonyl group at C-9 in Clarithromycin core and hydroxy-borole moiety. This could facilitate nucleophilic attack of methanol used in reactions to destroy benzo[c][1,2]oxaboroles fragments and leave stable hydroxyl-aryl molecules.Conclusion: The loss of boron from benzo[c][1,2]oxoborole fragments leads to the significant decrease of antimicrobial activity of synthesized antibiotics.Keywords: Macrolactone, macrolide, clarithromycin, benzoxaborole, 1-hydroxy-1, 3-dihydroben-zo[c][1, 2]oxaborole, antibacterial, conjugates of antibiotics, deboronation.https://doi.org/10.2174/2211352517666181122130101
Добавил в систему: Лапа Геннадий Борисович

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Deboronation of New Clarithromycin-Benzo[c][1,2]oxaborole Conjugatesстатья

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