|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
АНТИВОСПАЛИТЕЛЬНОЕ ДЕЙСТВИЕ АГОНИСТОВ РЕЦЕПТОРО 1 ТИПА, АКТИВИРУЕМЫХ ПРОТЕАЗАМИ, НА КЛЕТКИ ЛИНИИ RBL-2H3 ПРИ ГИПЕРГЛИКЕМИИтезисы доклада
- Авторы: Бабкина И.И., Голяко И.А., Сидорова М.В., Струкова С.М., Горбачёва Л.Р.
- Сборник: Нейронаука для медицины и психологии: 12-й Международный междисциплинарный конгресс. Труды Конгресса
- Тезисы
- Год издания: 2016
- Место издания: МАКС Пресс Москва
- Первая страница: 74
- Последняя страница: 76
- Аннотация: It is known that the effect of Tr on the inflammatory response depends from its concentration. Previously we have shown that Tr 50 nM leads to the development of the inflammatory response on cultured astrocytes. In the present study, it has been found that a pretreatment cells with 10 nM APC and AP9 before the ionophore A23187 increases proliferation, which was decreased by ionophore. At normoglycemia A23187 toxic effect was higher than at hyperglycemia. It is shown that Tp didn’t demonstrate pro-inflammatory action at normoglycemia, but the increased glucose led to the development of a proinflammatory cell response on Tr 50 nM. The incubation of cells in the presence of APC and AP9 did not alter the level of secretion of RBL-2H3 at normoglycemia similar Tr. At hyperglycemia APC and AP9 in contrast to Tr reduced the ionophore-induced secretion of cells. Thus, it was found that hyperglycemia potentiates the pro-inflammatory effect of Tr and anti-inflammatory effects of APC and its peptide-analog. Drugs based on APC and AP9 can be used for anti-inflammatory therapy in patients with impaired glucose metabolism.
- Добавил в систему: Горбачева Любовь Руфэльевна