Аннотация:The protein fraction isolated from blood of seal, Phoca groenlandica, has been found to
produce hyperalgesic effect on rats exposed to thermic or electrocutaneous nociceptive
stimulation, but fail to affect writhes provoked by intraperitoneal injection of acetic acid
solution on mice. When combined with morphine, the fraction lowered completely its narcotic
analgetic action in the above mentioned tests. On the contrary, these same proteins
combined with promedol or fentanil enhanced and prolonged analgetic effect of the latter.