Three DNA Polymorphisms Previously Identified as Markers for Handgrip Strength Are Associated With Strength in Weightlifters and Muscle Fiber Hypertrophy

Grishina, E.E.; Piotr, Z.; Semenova, E.A.; Paweł, C.; ska Lisowska, K.H.; Monika, M.; Ewelina, M.; Blair, C.; Joanna, O.; Kostryukova, E.S.; Kulemin, N.A.; Borisov, O.V.; Khabibova, S.A.; Larin, A.K.; Pavlenko, A.V.; Lyubaeva, E.V.; Popov, D.V.; Lysenko, E.A.; Vepkhvadze, T.F.; Lednev, E.M.; Bondareva, E.A.; Erskine, R.M.; Generozov, E.V.; Ildus, I.A.

Авторы: Grishina Elina E., Piotr Zmijewski, Semenova Ekaterina A., Paweł Cie˛szczyk, ska Lisowska Kinga Humin´, Monika Michałowska-Sawczyn, Ewelina Maculewicz, Blair Crewther, Joanna Orysiak, Kostryukova Elena S., Kulemin Nickolay A., Borisov Oleg V., Khabibova Sofya A., Larin Andrey K., Pavlenko Alexander V., Lyubaeva Ekaterina V., Popov Daniil V., Lysenko Evgeny A., Vepkhvadze Tatiana F., Lednev Egor M., Bondareva Elvira A., Erskine Robert M., Generozov Edward V., and Ildus I.Ahmetov
Журнал: Journal of Strength and Conditioning Research
Том: 33
Номер: 10
Год издания: 2019
Издательство: National Strength and Conditioning Association
Местоположение издательства: United States
Первая страница: 2602
Последняя страница: 2607
DOI: 10.1519/JSC.0000000000003304
Аннотация: Muscle strength is a highly heritable trait. So far, 196 single nucleotidepolymorphisms (SNPs) associated with handgrip strength have been identified in 3 genome-wide association studies. The aim ofour study was to validate the association of 35 SNPs with strength of elite Russian weightlifters and replicate the study in Polishweightlifters. Genotyping was performed using micro-array analysis or real-time polymerase chain reaction. We found that thers12055409 G-allele near the MLN gene (p 5 0.004), the rs4626333 G-allele near the ZNF608 gene (p 5 0.0338), and thers2273555 A-allele in the GBF1 gene (p 5 0.0099) were associated with greater competition results (total lifts in snatch and cleanand jerk adjusted for sex and weight) in 53 elite Russian weightlifters. In the replication study of 76 sub-elite Polish weightlifters,rs4626333 GG homozygotes demonstrated greater competition results (p 5 0.0155) and relative muscle mass (p 5 0.046),adjusted for sex, weight, and age, compared with carriers of the A-allele. In the following studies, we tested the hypotheses thatthese SNPs would be associated with skeletal muscle hypertrophy and handgrip strength. We found that the number of strengthassociatedalleles was positively associated with fast-twitch muscle fiber cross-sectional area in the independent cohort of 20 malepower athletes (p 5 0.021) and with handgrip strength in 87 physically active individuals (p 5 0.015). In conclusion, by replicatingprevious findings in 4 independent studies, we demonstrate that the rs12055409 G-, rs4626333 G-, and rs2273555 A-alleles areassociated with higher levels of strength, muscle mass, and muscle fiber size.Key Words: strength performance, muscle hypertrophy, gene, genotype
Добавил в систему: Бондарева Эльвира Александровна

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Three DNA Polymorphisms Previously Identified as Markers for Handgrip Strength Are Associated With Strength in Weightlifters and Muscle Fiber Hypertrophyстатья Исследовательская статья

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