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Pre-bilaterian origin of the blastoporal axial organizerстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus,
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 июня 2016 г.
- Авторы: Kraus Y., Aman A., Technau U., Genikhovich G.
- Журнал: Nature communications
- Том: 7
- Номер: 11694
- Год издания: 2016
- Издательство: Nature Pub. Group
- Местоположение издательства: United Kingdom
- Первая страница: 1
- Последняя страница: 9
- DOI: 10.1038/ncomms11694
- Аннотация: The startling capacity of the amphibian Spemann organizer to induce naı¨ve cells to form a Siamese twin embryo with a second set of body axes is one of the hallmarks of developmental biology. However, the axis-inducing potential of the blastopore-associated tissue is commonly regarded as a chordate feature. Here we show that the blastopore lip of a non-bilaterian metazoan, the anthozoan cnidarian Nematostella vectensis, possesses the same capacity and uses the same molecular mechanism for inducing extra axes as chordates: Wnt/b-catenin signaling. We also demonstrate that the establishment of the secondary, directive axis in Nematostella by BMP signaling is sensitive to an initial Wnt signal, but once established the directive axis becomes Wnt-independent. By combining molecular analysis with experimental embryology, we provide evidence that the emergence of the Wnt/b-catenin driven blastopore-associated axial organizer predated the cnidarian-bilaterian split over 600 million years ago.
- Добавил в систему: Краус Юлия Александровна