Use of solid-phase inhomogeneities to increase the efficiency of ultrasonic therapy of oncological diseasesстатья
Информация о цитировании статьи получена из
Web of Science ,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Авторы:
Nikolaev A.L. ,
Gopin A.V. ,
Bozhevol’nov V.E. ,
Treshchalina E.M.,
Andronova N.V.,
Melikhov I.V.
Журнал:
Acoustical Physics
Том:
55
Номер:
4-5
Год издания:
2009
Издательство:
Maik Nauka/Interperiodica Publishing
Местоположение издательства:
Russian Federation
Первая страница:
575
Последняя страница:
583
DOI:
10.1134/S1063771009040149
Аннотация:
Authors’ concepts on the use of solid-phase sonosensitizer nanoinclusions in biological structures as ultrasonic energy concentrators in the therapy of oncological diseases are developed. The possibility of directed synthesis of nanoparticles and their aggregates in tumor tissue depending on its growth features is discussed. It was found that acoustic effects in polymer structures containing solid-phase inclusions depend on the nature of these inclusions and their bond with the polymer matrix. Using model gel systems, it was shown that solid-phase sonosensitizers enhance local thermal effects and amplitude-dependent scattering of ultrasound during its propagation in gel. Experimental studies on animals showed that the ultrasound exposure of malignant tumors containing nanoparticles of gold and some complex compounds results in a significant therapeutic effect. В© 2009 Pleiades Publishing, Ltd.
Добавил в систему:
Гопин Александр Викторович