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Prokaryotic-like cis elements in the cap-independent internal initiation of translation on picornavirus RNAстатья
Информация о цитировании статьи получена из
Scopus,
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Pilipenko E.V., Gmyl A.P., Maslova S.V., Svitkin Y.V., Sinyakov A.N., Agol V.I.
- Журнал: Cell
- Том: 68
- Номер: 1
- Год издания: 1992
- Издательство: Cell Press
- Местоположение издательства: United States
- Первая страница: 119
- Последняя страница: 131
- Аннотация: Initiation of translation on picornavirus RNAs is accomplished through internal binding of ribosomes to a complex cis-acting element. Here we show that efficient function of this element involves two appropriately spaced smaller elements: UUUCC and an AUG. This conclusion emerged from analysis of the genome structures of spontaneous revertants of mutant polioviruses with extended insertions between the UUUCC and AUG motifs. It was confirmed by the results obtained with specially designed constructs. A similarity to the prokaryotic translation initiation mechanism, which involves the Shine-Dalgarno sequence, is emphasized, but in the picornavirus system the position of the UUUCC must be strictly fixed relative to upstream cis-acting elements, and the AUG may not necessarily serve as an initiation codon.
- Добавил в систему: Гмыль Анатолий Петрович