|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
Reconstruction of new ancient Mycobacterium leprae genomes from Europeтезисы доклада
- Авторы: Saskia Pfrengle, Judith Neukamm, Sarah Inskip, Tukhbatova Rezeda I., Ella Reiter, Nataliya Berezina, Buzhilova Alexandra P., Stian Suppersberger Hamre, Vítor Matos, Maria Teresa Ferreira, Johannes Krause, Schuenemann Verena J.
- Сборник: ISEMPH2019: INTERNATIONAL SOCIETY FOR EVOLUTION, MEDICINE, AND PUBLIC HEALTH 2019 FULL PROGRAM WITH ABSTRACTS
- Тезисы
- Год издания: 2019
- Место издания: Zurich
- Первая страница: 63
- Последняя страница: 64
- Аннотация: Leprosy is one of the oldest known diseases in human history with possible osteoarchaeological cases dating back till the Late Copper Age (3,650 BC) in Hungary. Molecular biological approaches, such as ancient DNA research focussing on the causative agent, Mycobacterium leprae, can greatly contribute towards understanding the evolutionary history of the disease. Previous genetic studies of ancient M. leprae genomes in comparison with modern strains have identified genomic continuity over the last 1,000 years and the existence of at least four lineages in medieval Europe. However, the ancient genomes published so far concentrate on certain regions of Europe which probably do not reflect the diversity of other regions. Here, we address this issue through the genetic examination of several medieval and post-medieval samples from so far unstudied regions. Up to now, three new ancient M. leprae genomes have been already reconstructed: two medieval genomes from Portugal (1,340 ± 48 AD) and Norway (1,328 ± 60 AD) and a genome from Russia dated to the 19th-20th century. Ongoing analysis is focuses on the reconstruction of additional ancient leprosy genomes in order to more fully capture the diversity of the ancient M. leprae strains in Europe. The phylogenetic analysis of the reconstructed genomes, including previously published modern and ancient genomes, reveals that the genomes from Portugal and Norway fall on branch 3. The genome from Russia is located on branch 2F and clusters with modern Ethiopian strains. Overall, our results contribute to a better understanding of the past diversity of leprosy in Europe by adding genomic data from so far unstudied regions.
- Добавил в систему: Березина Наталия Яковлевна