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Relative brain weight differences as the result of direct and indirect selectionтезисы доклада Электронная публикация
- Авторы: Ogienko N.A., Perepelkina O.V., Lilp I.G., Poletaeva I.I.
- Сборник: Тезисы международной конференции 21nd Annual Genes, Brain and Behavior Meeting University of Edinburgh May 10th-14th, 2019
- Тезисы
- Год издания: 2019
- Место издания: Edinburgh, Scotland, UK
- Первая страница: 64
- Последняя страница: 65
- Аннотация: The differences in the brain weight -the trait, connected to the level of animal cognition,- is usually evaluated comparing the respective scores in different taxa. The selection of laboratory mice for large and small relative brain weight is one of the techniques which permit to evaluate the role of this variable at the intraspecies level. Three selection experiments were performed in our laboratory, their results being more or less similar- with higher cognitive capacities in Large Brain line and higher indices of anxiety and stress reactivity in Small Brain mice. The selection for contrast values of this trait had been stopped at the level of F22 in the third experiment, and the two lines were randomly bred, now for 15 generations. The relative brain weight and behavioral differences stayed during breeding without selection. Large Brain mice were higher in cognitive task solution than Small Brain animals. The “puzzle-box” cognitive task was used, which requires the understanding of “object permanence rule”. At the same time the selection for high scores of cognitive task solution resulted in higher scores of the brain weight in the selected strain. This means, that in laboratory mice (very popular among neurobiologists) the brain weight values could indicate the cognitive capacities level. https://easychair.org/smart-program/GBB2019/2019-05-13.html
- Добавил в систему: Перепелкина Ольга Викторовна