Radiopharmaceuticals Based on Alpha Emitters: Preparation, Properties, and Applicationстатья
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Дата последнего поиска статьи во внешних источниках: 11 ноября 2019 г.
Аннотация:In this review, the problems of the development of radiopharmaceuticals (RPs) based on alphaemitting radionuclides are discussed. The prospects of application of the radionuclides 227 Th, 225 Ac, 223 Ra, 213 Bi, 212 Pb/ 212 Bi, 212 Bi, 211 At, and 149 Tb are estimated in the aspect of their physicochemical properties, such as half-life, properties of daughter radionuclides, and complexing ability. The methods used for the production of radionuclides and their industrial availability are considered. Some examples of radionuclide complexes with ligands and nanoparticles for targeted delivery are presented. The results of medical trials for RPs based on alpha emitters are given.