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Genetics of Adaptation of the Ascomycetous Fungus Podospora anserina to Submerged Cultivationстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 января 2020 г.
- Авторы: Kudryavtseva Olga A., Safina Ksenia R., Vakhrusheva Olga A., Logacheva Maria D., Penin Aleksey A., Neretina Tatiana V., Moskalenko Viktoria N., Glagoleva Elena S., Bazykin Georgii A., Kondrashov Alexey S.
- Журнал: Genome biology and evolution
- Том: 11
- Номер: 10
- Год издания: 2019
- Издательство: Oxford University Press
- Местоположение издательства: United Kingdom
- Первая страница: 2807
- Последняя страница: 2817
- DOI: 10.1093/gbe/evz194
- Аннотация: Podospora anserina is a model ascomycetous fungus which shows pronounced phenotypic senescence when grown on solid medium but possesses unlimited lifespan under submerged cultivation. In order to study the genetic aspects of adaptation of P. anserina to submerged cultivation, we initiated a long-term evolution experiment. In the course of the first 4 years of the experiment, 125 single-nucleotide substitutions and 23 short indels were fixed in eight independently evolving populations. Six proteins that affect fungal growth and development evolved in more than one population; in particular, in the G-protein alpha subunit FadA, new alleles fixed in seven out of eight experimental populations, and these fixations affected just four amino acid sites, which is an unprecedented level of parallelism in experimental evolution. Parallel evolution at the level of genes and pathways, an excess of nonsense and missense substitutions, and an elevated conservation of proteins and their sites where the changes occurred suggest that many of the observed fixations were adaptive and driven by positive selection.
- Добавил в систему: Неретина Татьяна Владимировна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | evz194.pdf | evz194.pdf | 560,1 КБ | 24 октября 2019 [KudruavtsevaOA] |