Cardiovascular system and intermittent stress: Bloodless adaptation to blood lossстатьяТезисы
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Дата последнего поиска статьи во внешних источниках: 1 апреля 2020 г.
Аннотация:An attempt has been made to use adaptation to stress for protection against the damaging action of acute blood loss. The experiments were carried out on male Wistar rats. Adaptation to stress was performed during 12 days by 1 h immobilization a day. After termination of the adaptation course, haemorrhagic shock was simulated in narcotized animals using catheterization of the femoral artery and multiple bleeding for 1 hour at arterial pressure of 40 mm Hg. Adaptation to intermittent stress induced specific changes in the hemodynamic parameters, the gas transport function, the acid-base state of the blood as well as the parameters of lipid peroxidation and the antioxidant status of different organs. They reflect enhanced resistance of stress- adapted rats to hypoxia. The data obtained suggest that haemorrhagic shock in adapted animals induces less pronounced changes in the tissue levels of 0, uptake in comparison with non-adapted ones. Adaptation increases the activities of endogenous antioxidants and the resistance to lipid peroxidation. Preliminary adaptation increases the lifetime in animals with haemorrhagic shock due to enhanced protection of the circulatory bed and the vital organs. All this makes adaptation to stress a promising and efficient procedure for increasing the resistance of the organism to bleeding and hemorrhagic shock. Supported by RFBR grant No 01-04-48252.