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Model of membrane fusion: Continuous transition to fusion pore with regard of hydrophobic and hydration interactionsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 августа 2016 г.
- Авторы: Akimov S.A., Molotkovsky R.J., Galimzyanov T.R., Radaev A.V., Shilova L.A., Kuzmin P.I., Batishchev O.V., Voronina G.F., Chizmadzhev Yu A.
- Журнал: Biologicheskie Membrany
- Том: 31
- Номер: 1
- Год издания: 2014
- Издательство: Biologicheskie Membrany
- Местоположение издательства: Russian Federation
- Первая страница: 14
- Последняя страница: 24
- Оригинальные версии: Модель слияния мембран: непрерывный переход в пору слияния с учетом гидрофобных и гидратационных взаимодействий
- DOI: 10.7868/S0233475514010022
- Аннотация: The process of membranes fusion is theoretically considered from stage of minimal radius stalk to formation of fusion pore. It is assumed that expanding stalk transforms directly to fusion pore bypassing trilaminar structure. The energy of the intermediate states is calculated on the basis of the classical theory of elasticity of liquid crystals, adapted to lipid membranes. The trajectory of transition of stalk to pore is obtained taking into account hydrophobic and hydration interactions. Along the trajectory there is a continuous change of orientation of lipids of distal monolayers from direction along the axis of rotation, characteristic to stalk, to the direction corresponding to the fusion pore. The dependence of the energy of the intermediate states on spontaneous curvature of distal monolayers of merging membranes is obtained. It is shown that the energy barrier of transition of stalk to fusion pore decreases with positive spontaneous curvature of distal monolayers, which is in agreement with available experimental data.
- Добавил в систему: Рубин Андрей Борисович