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[The positional isomers of triglycerides in oils, fats and apoB-100 lipoproteins: palmitic and oleic modes of metabolism of fatty acids-substrates for energy acquiring]статья
- Авторы: Kotkina T.I., Titov V.N.
- Журнал: Klinicheskaia laboratornaia diagnostika
- Номер: 1
- Год издания: 2014
- Первая страница: 22
- Последняя страница: 6, 39-43
- Аннотация: Even total resemblance of content of fatty acids in triglycerides has both no standing for their functional unity nor even identity of their physical chemical characteristics. The etherification of fatty acids in various positions of three-atomic glycerin separates triglycerides on palmitic and oleic substrates for energy acquiring by cells. The kinetic parameters of biochemical reactions under palmitic mode of metabolism of fatty acids are always low. The myocytes in biological reaction of exotrophy experience deficiency of exogenous fatty acids which in vivo is to permanently supply through activation of biological reaction of endotrophy--enhancement of lipolysis in adipocytes. The biological role of insulin is to prevent formation in vivo of palmitic mode of metabolism of saturated and monoenic fatty acids. Under this condition, the necessity to activate lipolysis and to increase in blood plasma concentration of unesteritied fatty acids forms syndrome of resistance to insulin. The surplus of palmitic fatty acid in food and deficiency of insulin show in vivo unidirectional a physiologic action. The formation of palmitic mode of metabolism of energy substrates--portion of pathogenesis of atherosclerosis, metabolic syndrome, obesity, non-alcoholic fatty infiltration of liver and partiallly essential arterial hypertension.
- Добавил в систему: Титов Владимир Николаевич