Recent advances in metallopolymer-based drug delivery systems (review)статья
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Дата последнего поиска статьи во внешних источниках: 24 января 2020 г.
Аннотация:Metallopolymers (MPs) or metal-containing polymers have shown great potential as new drug delivery
systems (DDSs) due to their unique properties, including universal architectures, composition, properties
and surface chemistry. Over the past few decades, the exponential growth of many new classes of MPs
that deal with these issues has been demonstrated. This review presents and assesses the recent
advances and challenges associated with using MPs as DDSs. Among the most widely used MPs for
these purposes, metal complexes based on synthetic and natural polymers, coordination polymers,
metal–organic frameworks, and metallodendrimers are distinguished. Particular attention is paid to the
stimulus- and multistimuli-responsive metallopolymer-based DDSs. Of considerable interest is the use of
MPs for combination therapy and multimodal systems. Finally, the problems and future prospects of
using metallopolymer-based DDSs are outlined. The bibliography includes articles published over the
past five years.