The microtubule skeleton and the evolution of neuronal complexity in vertebratesстатья
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Дата последнего поиска статьи во внешних источниках: 20 ноября 2019 г.
Аннотация:The evolution of a highly developed nervous system is mirrored by the ability of
individual neurons to develop increased morphological complexity. As microtubules
(MTs) are crucially involved in neuronal development, we tested the hypothesis
that the evolution of complexity is driven by an increasing capacity of the MT
system for regulated molecular interactions as it may be implemented by a higher
number of molecular players and a greater ability of the individual molecules to
interact. We performed bioinformatics analysis on different classes of components
of the vertebrate neuronal MT cytoskeleton. We show that the number of orthologs
of tubulin structure proteins, MT-binding proteins and tubulin-sequestering
proteins expanded during vertebrate evolution. We observed that protein diversity
of MT-binding and tubulin-sequestering proteins increased by alternative
splicing. In addition, we found that regions of the MT-binding protein tau and
MAP6 displayed a clear increase in disorder extent during evolution. The data
provide evidence that vertebrate evolution is paralleled by gene expansions,
changes in alternative splicing and evolution of coding sequences of components
of the MT system. The results suggest that in particular evolutionary changes in
tubulin-structure proteins, MT-binding proteins and tubulin-sequestering proteins
were prominent drivers for the development of increased neuronal complexity.