Аннотация:Abstract. The study presents experimental data on the combined application of ozonized physiological solution with a low concentration of ozone and photodynamic therapy with the intratumoral introduction of the photosensitizer "Photosens". Anti-tumor efficacy of the developed treatment regimen, as well as the correction of free radical processes in tumor-bearing animals and low genotoxic effect were shown.
Key words: ozone, photodynamic therapy, free radical processes, comet assay, cancer.
Conclusions
The experimental scheme of ozone-photodynamic therapy developed causes tumor regression and has a reduced risk of stimulating the tumor growth compared to mono-PDT. The protection effect of the combined action of PDT and OPS is manifested as a decrease in the level of DNA damage in normal cells.
The work was supported by the Russian Foundation for Basic Research (project 19-02-00667).
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