Inhibitors of Glyceraldehyde 3-Phosphate Dehydrogenase and Unexpected Effects of Its Reduced Activityстатья
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Дата последнего поиска статьи во внешних источниках: 27 ноября 2019 г.
Аннотация:The review describes the use of glyceraldehyde 3-phosphate dehydrogenase (GAPDH)
inhibitors to study the enzyme and to suppress its activity in various cell
types. The main problem of selective GAPDH inhibition is a highly conserved
nature of the enzyme active site and, especially, Cys150 environment important
for the catalytic action of cysteine sulfhydryl group. Numerous attempts to find
specific inhibitors of sperm GAPDH and enzymes from Trypanosoma sp. and
Mycobacterium tuberculosis that would not inhibit GAPDH of somatic mammalian
cells have failed, which has pushed researchers to search for new ways to solve
this problem. The sections of the review are devoted to the studies of GAPDH
inactivation by reactive oxygen species, glutathione, and glycating agents. The
final section discusses possible effects of GAPDH inhibition and inactivation on
glycolysis and related metabolic pathways (pentose phosphate pathway, uncoupling
of the glycolytic oxidation and phosphorylation, etc.).