|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
Alpha and beta oscillations in rest and during voluntary movements in STN of Parkinsonian patientsтезисы доклада
- Авторы: Belova E., Semenova U., Tomskiy A., Sedov A.
- Сборник: Abstract book of XIIIth IBAGS Meeting, April 28 - May 2, 2019, Biarritz, France
- Тезисы
- Год издания: 2019
- Место издания: International Basal Ganglia Society
- Первая страница: 137
- Последняя страница: 137
- Аннотация: Oscillatory activity in subthalamic nucleus (STN) is under extensive study as it may contribute to both normal motor control in basal ganglia and in it’s pathophysiological impairment in Parkinson’s disease (PD). However, the particular borders of beta oscillatory range that is considered to be pathological are chosen arbitrarily. They may vary from 8 to 15 Hz for the lower limit, thus capturing occasionally a part or the whole alpha range into consideration. Here we studied the features of local field potential (LFP) rhythmic activity in alpha (8-12 Hz), low (12-20 Hz) and high (20-30 Hz) beta ranges at rest and during voluntary movements using novel algorithm for automatic parameterization of neural power spectral densities as a combination of the aperiodic signal and putative periodic oscillations (Voitek et al. 2015). This approach allows to estimate aperiodic "background" 1/f component from the slope of the LFP spectras which may reflect excitation/inhibition ratio in neuronal population. 31 patients with PD undergoing DBS surgery were included in the study. LFPs were recorded during rest and motor tests (patient were asked to contract fist and/or move foot contralateral to the hemisphere recorded). At rest oscillations in both low and high beta range were significantly higher in dorsal part of STN, whereas alpha oscillations were stronger more ventrally. Motor tests led to the significant decrease in the spectral slope and the increase in low beta range. The most pronounced changes in the slope and in the low beta oscillation scores were found in dorsal part of STN. At the same time, alpha and high beta ranges during voluntary movements remained substantially unaffected. We believe that alpha, low and high beta ranges must be considered separately in neurophisiological research of basal ganglia. This work was supported within frameworks of the state task for ICP RAS 0082- 2014-0001 (state registration #АААА-А17-117040610310-6) and RFBR grant #18- 015-00140
- Добавил в систему: Гамалея Анна Александровна