The generalized and myoclonic seizures in Krushinsky-Molodkina rat strain

Авторы: Fedotova I.B., Poletaeva I.I.
Сборник: 21 st Annual meeting of the International Behavioural and Neural Genetics Society (IBANGS), May 10-14th, 2019, Edinburgh, United Kingdom,
Тезисы
Год издания: 2019
Аннотация: Krushinsky-Molodkina (KM) rat strain was the first one in the range of similar genetic models, created in the late 1940s. When exposed to loud sound develop clonic (in 2-3 sec) and tonic (in 7-10 sec) convulsions. The daily sound exposure results in 15-12 days) with the development of myoclonic seizures, starting with face muscle jerks spreading to neck and body musculature. This phenomenon was described in other audiogenic prone rat strains and represents the typical seizure kindling. As the TLE symptoms in humans include also numerous rather serious psychiatric disorders (apart from myoclonus fits) the KM rat strain could represent the model of complicated changes development in brain structures similar and parallel to those in humans (when the long history of generalized seizures invokes the TLE symptoms).
Добавил в систему: Федотова Ирина Борисовна

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