Biological diversity and remodeling of cardiolipin in oxidative stress and age-related pathologies

Shilovsky, G.A.; Putyatina, T.S.; Ashapkin, V.V.; Yamskova, O.V.; Lyubetsky, V.A.; Sorokina, E.V.; Shram, S.I.; Markov, A.V.; Vyssokikh, M.Y.

Авторы: Shilovsky G.A., Putyatina T.S., Ashapkin V.V., Yamskova O.V., Lyubetsky V.A., Sorokina E.V., Shram S.I., Markov A.V., Vyssokikh M.Y.
Журнал: Biochemistry (Moscow)
Том: 84
Номер: 12-13
Год издания: 2019
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
Первая страница: 1469
Последняя страница: 1483
Оригинальные версии: Биологическое разнообразие кардиолипина и его ремоделирование при окислительном стрессе и возрастных патологиях
DOI: 10.1134/S000629791912006X
Аннотация: Age-related dysfunctions are accompanied by impairments in the mitochondrial morphology, activity of signaling pathway, and protein interactions. Cardiolipin is one of the most important phospholipids that maintains the curvature of the cristae and facilitates assembly and interaction of complexes and supercomplexes of the mitochondrial respiratory chain. The fatty acid composition of cardiolipin influences the biophysical properties of the membrane and, therefore, is crucial for the mitochondrial bioenergetics. The presence of unsaturated fatty acids in cardiolipin is the reason of its susceptibility to oxidative damage. Damaged cardiolipin undergoes remodeling by phospholipases, acyltransferases, and transacylases, creating a highly specific fatty acyl profile for each tissue. In this review, we discuss the variability of cardio-lipin fatty acid composition in various species and different tissues of the same species, both in the norm and at various pathologies (e.g., age-related diseases, oxidative and traumatic stresses, knockouts/knockdowns of enzymes of the cardio-lipin synthesis pathway). Progressive pathologies, including age-related ones, are accompanied by cardiolipin depletion and decrease in the efficiency of its remodeling, as well as the activation of an alternative way of pathological remodeling, which causes replacement of cardiolipin fatty acids with polyunsaturated ones (e.g., arachidonic or docosahexaenoic acids). Drugs or special diet can contribute to the partial restoration of the cardiolipin acyl profile to the one rich in fatty acids characteristic of an intact organ or tissue, thereby correcting the consequences of pathological or insufficient cardiolipin remodeling. In this regard, an urgent task of biomedicine is to study the mechanism of action of mitochondria-targeted antioxi-dants effective in the treatment of age-related pathologies and capable of accumulating not only in vitro, but also in vivo in the cardiolipin-enriched membrane fragments.
Добавил в систему: Любецкий Василий Александрович

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