Association between Antiarrhythmic, Electrophysiological and Antioxidative Effects of Melatonin in Ischemia/Reperfusion

Sedova, K.A.; Bernikova, O.G.; Cuprova, J.I.; Ivanova, A.D.; Kutaeva, G.A.; Pliss, M.G.; Lopatina, E.V.; Vaykshnorayte, M.A.; Diez, E.R.; Azarov, J.E.

Авторы: Sedova Ksenia A., Bernikova Olesya G., Cuprova Julia I., Ivanova Alexandra D., Kutaeva Galina A., Pliss Michael G., Lopatina Ekaterina V., Vaykshnorayte Marina A., Diez Emiliano R., Azarov Jan E.
Журнал: International Journal of Molecular Sciences
Том: 20
Номер: 24
Год издания: 2019
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 6331
Последняя страница: 6346
DOI: 10.3390/ijms20246331
Аннотация: Melatonin is assumed to confer cardioprotective action via antioxidative properties. We evaluated the association between ventricular tachycardia and/or ventricular fibrillation (VT/VF) incidence, oxidative stress, and myocardial electrophysiological parameters in experimental ischemia/reperfusion under melatonin treatment. Melatonin was given to 28 rats (10 mg/kg/day, orally, for 7 days) and 13 animals received placebo. In the anesthetized animals, coronary occlusion was induced for 5 min followed by reperfusion with recording of unipolar electrograms from ventricular epicardium with a 64-lead array. Effects of melatonin on transmembrane potentials were studied in ventricular preparations of 7 rats in normal and “ischemic” conditions. Melatonin treatment was associated with lower VT/VF incidence at reperfusion, shorter baseline activation times (ATs), and activation-repolarization intervals and more complete recovery of repolarization times (RTs) at reperfusion (less baseline-reperfusion difference, ΔRT) (p < 0.05). Superoxide dismutase (SOD) activity was higher in the treated animals and associated with ΔRT (p = 0.001), whereas VT/VF incidence was associated with baseline ATs (p = 0.020). In vitro, melatonin led to a more complete restoration of action potential durations and resting membrane potentials at reoxygenation (p < 0.05). Thus, the antioxidative properties of melatonin were associated with its influence on repolarization duration, whereas the melatonin-related antiarrhythmic effect was associated with its oxidative stress-independent action on ventricular activation.
Добавил в систему: Иванова Александра Дмитриевна

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Association between Antiarrhythmic, Electrophysiological and Antioxidative Effects of Melatonin in Ischemia/Reperfusionстатья

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