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Effect of organic ligands with conjugated π-bonds on the structure of iodine-α-dextrin complexesстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Yuldasheva G.A., Zhidomirov G.M., Ilin A.I.
- Журнал: Biotechnology and Applied Biochemistry
- Том: 59
- Номер: 1
- Год издания: 2012
- Издательство: Portland Press, Ltd.
- Местоположение издательства: United Kingdom
- Первая страница: 29
- Последняя страница: 34
- DOI: 10.1002/bab.70
- Аннотация: Using X-ray data for iodine-α-dextrin complexes and the results of quantum chemical ab initio restricted Hartree-Fock/3-21G ** level calculations, a model of drug active complex (AC) Armenicum with anti-HIV action was proposed. It was suggested that the drug AC contains molecular iodine allocated inside of α-dextrin helix and coordinated by lithium halogenides and a protein component of lymphocyte ribosomes. The electronic structure of I 2 in this complex differs from its characteristics in complexes with organic ligands or the free I 2. In the considered ACs, the molecular iodine displays acceptor (donor) properties toward the α-dextrins (lithium halogenides). A mechanism of Armenicum anti-HIV action is suggested. Under the influence of molecular iodine-containing drug AC, the structure of HIV DNA is modified-it becomes more π-donor-active against proteins and peptide nucleotides of viral DNA form a stable complex with molecular iodine and lithium halogenides. Copyright © 2012 International Union of Biochemistry and Molecular Biology, Inc.
- Добавил в систему: Жидомиров Георгий Михайлович