Modulation of hippocampal neuron survival by thrombin and factor Xaстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 7 октября 2013 г.
Местоположение издательства:Road Town, United Kingdom
Первая страница:1082
Последняя страница:1089
Аннотация:Effects of thrombin, factor Xa (FXa), and protease-activated receptor 1 and 2
agonist peptides (PAR1-AP and PAR2-AP) on survival and intracellular Ca2+
homeostasis in hippocampal neuron cultures treated with cytotoxic doses of
glutamate were investigated. It is shown that at low concentrations (<or=10 nM)
thrombin and FXa protect neurons from glutamate-induced excitotoxicity.
Inactivation of the proteases blocked the neuroprotective effect. Using PAR1-AP,
PAR2-AP, and PAR1 antagonist, we have demonstrated that the neuroprotective
effect of thrombin is mediated through activation of PAR1, whereas the effect of
FXa may involve novel subtype(s) of PARs. Unlike FXa, thrombin induced transient
intracellular calcium signal in hippocampal neurons, which was mainly mediated
via IP(3) receptors of the endoplasmic reticulum. Both of the serine proteases
improved the recovery of neuronal Ca2+ homeostasis after glutamate treatment.