Peptidoglycane Immunomax increases humoral and cell immune responses of mice to recombinant proteins of hepatitis C virus

Авторы: Masalova O.V., Lesnova E.I., Pichugin A.V., Melnikova T.M., Ataullakhanov R.I., Kustch A.A.
Сборник: 2ND EUROPEAN CONGRESS OF IMMUNOLOGY (ECI)
Тезисы
Год издания: 2009
Первая страница: 469
Последняя страница: 472
Аннотация: The aim of study was in evaluable the immunogenicity of covalent conjugates recombinant nonstructural NS4 and NS5A of hepatitis C virus (HCV) proteins with peptidoglycane Immunomax(sic), which displays immunomodulating activity. BALB/c and DBA/2J mice were immunized intraperitoneally 2 times at a month interval with different doses (0.1 - 2 mu g/mouse) of the proteins without adjuvants, as conjugates with Immunomax, or with complete Freund's adjuvant. The NS4-Immunomax conjugate induced high antibody production at low protein doses (<2 mu g), the other combinations were not immunogenic at given doses. Only the conjugate induced splenic accumulation of T cells specifically reacting in vitro with different NS5A antigens by cell proliferation and/or cytokine secretion.
Добавил в систему: Хапчаев Шамиль Юсуфович

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