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Molecular Oxygen (a Substrate of the Cyclooxygenase Reaction) in the Kinetic Mechanism of the Bifunctional Enzyme Prostaglandin-H-synthaseстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 7 октября 2013 г.
- Авторы: Filimonov I.S., Vrzheshch P.V.
- Журнал: Biochemistry (Moscow)
- Том: 72
- Номер: 9
- Год издания: 2007
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 944
- Последняя страница: 953
- DOI: 10.1134/S0006297907090040
- Аннотация: Prostaglandin-H-synthase is a bifunctional enzyme catalyzing conversion of arachidonic acid into prostaglandin H2 as a result of cyclooxygenase and peroxidase reactions. The dependence of the rate of the cyclooxygenase reaction on oxygen concentration in the absence and in the presence of electron donor was determined. A two-dimensional kinetic scheme accounting for independent proceeding and mutual influence of the cyclooxygenase and peroxidase reactions and also for hierarchy of the rates of these reactions was used as a model. In the context of this model, it was shown that there are irreversible stages in the mechanism of the cyclooxygenase reaction between points of substrate donation (between donation of arachidonic acid and the first oxygen molecule and also between donation of two oxygen molecules).
- Добавил в систему: Филимонов Иван Сергеевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Molecular Oxygen (a Substrate of the Cyclooxygenase Reaction) in the Kinetic Mechanism of the Bifunctional Enzyme Prostaglandin-H-synthase | 2007_bcm_0944_0953_Filimonov.pdf | 241,1 КБ | 15 сентября 2014 [VrzheshchPV] |