The involvement of hypothalamic-pituitary-adrenal and monoaminergic systems genes in developing aggressive behaviourстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 7 июля 2020 г.
Аннотация:Despite frequent comorbidity of aggressive behavior (AB) with several psychopathologies and criminal antisocial behaviours, it is present in everyday life even at high extent thus representing an important social problem causing significant costs to society. It is known that AB is significantly hereditary, but specific gene-environmental (G × E) mechanisms mediating the genetic risk for aggression remain unclear.The present study aimed to estimate both the main effect of polymorphic variants and haplotypes of oxytocin receptor (OXTR: rs53576, rs237911, rs7632287, rs2254298, rs2228485, rs13316193), arginine-vasopressin receptor (AVPR1A: rs1042615, rs3803107; AVPR1B: rs33911258), monoamine oxidase B (MAOB: rs6651806), serotonin transporter (SLC6A4: 5-HTTLPR, rs1042173) and dopamine receptor (DRD4, rs1800955) genes and G × E-interactions in individual differences in AB in both clinical forms and mentally healthy individuals considering modulating effect of environmental factors.The present study provides evidence that OXTR, AVPR1B and SLC6A4 genetic variants may contribute to AB susceptibility together with environmental factors in clinical and non-clinical manifestations of AB.