|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
C<inf>60</inf> fullerene affects elastic properties and osmoregulation reactions of human lymphocytesстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 сентября 2016 г.
- Авторы: Skorkina M.Y., Sladkova E.A., Shamray E.A., Cherkashina O.V., Evstigneev M.P., Buchelnikov A.S., Prylutskyy Y.I., Ritter U.
- Журнал: European Biophysics Journal
- Том: 44
- Номер: 6
- Год издания: 2015
- Издательство: Springer Verlag
- Местоположение издательства: Germany
- Первая страница: 493
- Последняя страница: 498
- DOI: 10.1007/s00249-015-1050-9
- Аннотация: The influence of aqueous solution of pristine C<inf>60</inf> fullerene (C<inf>60</inf>FAS) on functional activity of lymphocytes from a healthy person was studied for the first time. By means of atomic force microscopy, it was found that C<inf>60</inf>FAS in a concentration of 0.1 mg/ml increases the stiffness of the lymphocyte membrane by 41 % (p < 0.05) and lowers the functional activity of the plasmalemma surface, thereby constraining the use of its membrane material in physiological reactions using a hypotonic model in vitro. However, a cell retains the ability to regulate its volume and demonstrates relative resistance to hypo-osmotic stress. The resistance of lymphocytes in hypo-osmotic medium is facilitated by activation of the nucleus by C<inf>60</inf> fullerene particles, which regulates the implementation of two consistent phases of an increase and decrease of cell volume, thereby retaining cell viability. All these indicate the impact of C<inf>60</inf> fullerene on the cellular nucleus. © 2015, European Biophysical Societies’ Association.
- Добавил в систему: Евстигнеев Максим Павлович