Comparing the efficacy of different types of repetitive navigated transcranial magnetic stimulation in treatment of pharmacoresistant spasticity in patients with multiple sclerosis: 20Hz rTMS, iTBS or placeboстатьяТезисы
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Дата последнего поиска статьи во внешних источниках: 8 февраля 2017 г.
Аннотация:Background: Spasticity is a significant factor in the
development of disability. Transcranial magnetic stimulation
(TMS) can be a promising tool for treatment.
Introduction: Our aim was to assess the efficacy of
navigated repetitive TMS (rTMS) in modulating lower limb
spasticity.
Methods: 13 patients (6 males, 7 females, mean age 45,64
± 11,47 years) with secondary progressive multiple sclerosis
and lower spastic paraparesis received 10 sessions of two
different types of rTMS or sham-stimulation over the motor
hotspot of the tibialis anterior muscle (table 1). We assessed
Modified Ashworth Scale (MAS), Modified Fatigue Impact
Scale 2 (MFIS 2), Expanded disability status scale (EDSS),
and Spasticity Subjective Evaluation Scale (SSES), pain
level scale, dysfunction of the pelvic organs before, at the
end of rTMS session, 2 and 12 weeks after.
Study design
Results: Patients who underwent both types of rTMS
sessions showed a reduction of spasticity on MAS (table 2).
There was no significant reduction of spasticity on MAS in
placebo group. There was significant reduction of spasticity
on SSES after iTBS protocol. This effect persisted for 12
weeks in most patients. In 20Hz and placebo group there
were no significant changes on SSES. After stimulation in
all 3 groups we noticed no significant differences in
influence on fatigue (MFIS2), pain level, dysfunction of the
pelvic organs.