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Rapid accumulation of mutations in growing mycelia of a hypervariable fungus Schizophyllum communeстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 февраля 2021 г.
- Авторы: Bezmenova Aleksandra V., Zvyagina Elena A., Fedotova Anna V., Kasianov Artem S., Neretina Tatiana V., Penin Aleksey A., Bazykin Georgii A., Kondrashov Alexey S.
- Журнал: Molecular Biology and Evolution
- Том: 37
- Номер: 8
- Год издания: 2020
- Издательство: Oxford University Press
- Местоположение издательства: United Kingdom
- Первая страница: 2279
- Последняя страница: 2286
- DOI: 10.1093/molbev/msaa083
- Аннотация: The basidiomycete Schizophyllum commune has the highest level of genetic polymorphism known among living organisms. In a previous study, it was also found to have a moderately high per generation mutation rate of 2x10−8, likely contributing to its high polymorphism. However, this rate has been measured only in an experiment on Petri dishes, and it is unclear how it translates to natural populations. Here, we used an experimental design that measures the rate of accumulation of de novo mutations in a linearly growing mycelium. We show that Sch. Commune accumulates mutations at a rate of 1.24x10−7 substitutions per nucleotide per meter of growth, or about 2.04x10−11 per nucleotide per cell division. In contrast to what has been observed in a number of species with extensive vegetative growth, this rate does not decline in the course of propagation of a mycelium. As a result, even a moderate per cell division mutation rate in Sch. Commune can translate into a very high per generation mutation rate when the number of cell divisions between consecutive eiosis is large.
- Добавил в систему: Федотова Анна Вячеславовна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Rapid_accumulation_of_mutations_in_growing_mycelia_of_a_hyp… | 769,5 КБ | 7 апреля 2020 [annavfedotova] |