Asymmetric oscillations of endoskeletal antibubbles

Kudo, N.; Uzbekov, R.E.; Ryunosuke, M.; Ri-ichiro, S.; Craig, C.; Nicole, A.; Aurélie, D.; Clement, P.; Poortinga, A.T.; Rubin, D.M.; Ayache, B.; Michiel, P.

Авторы: Nobuki Kudo, Uzbekov Rustem E., Ryunosuke Matsumoto, Ri-ichiro Shimizu, Craig Carlson, Nicole Anderton, Aurélie Deroubaix, Clement Penny, Poortinga Albert T., Rubin David M., Ayache Bouakaz, Michiel Postema
Журнал: Japanese Journal of Applied Physics
Том: 59
Номер: SK
Год издания: 2020
Издательство: Institute of Pure and Applied Physics
Местоположение издательства: Japan
Первая страница: 1
Последняя страница: 3
DOI: 10.35848/1347-4065/ab79e7
Аннотация: Antibubbles, i.e., gas bubbles containing an incompressible core, have been under investigation as potential vehicles in ultrasound-guided drug delivery. It is assumed that antibubbles can expand unhampered, but cannot contract beyond the size of their inner core. In this study, this so-called expansion-only hypothesis is tested on endoskeletal antibubbles and reference bubbles. Antibubbles and identical bubbles without a core were subjected to short 3-cycle pulses of 1-MHz ultrasound, whilst being recorded with a high-speed camera operating at 10 million frames per second. At low acoustic amplitudes (200 kPa), antibubbles and bubbles oscillated symmetrically. At high acoustic amplitudes (1.00 MPa), antibubbles and bubbles oscillated asymmetrically, but antibubbles significantly more so than bubbles. Furthermore, fragmentation and core release were observed at these amplitudes. The high-speed videos confirm the expansion-only hypothesis at 1-MPa acoustic amplitude at a transmitting frequency of 1 MHz. One short, high-amplitude pulse appeared to be enough to shatter antibubbles and release their core contents. This finding may have implications for ultrasound-guided drug delivery using antibubbles.
Добавил в систему: Узбеков Рустем Эдуардович

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