Аннотация:Previous studies of mechanisms of response inhibition revealed that the left brain hemisphere mainly relates to the Go/NoGo task performance while the right hemisphere is activated in the Stop-signal task. We compared fMRI activation in execution of these tasks in the study. We used BOLD-fMRI (GeneralElectric scanner, 1.5 T) and FSL software. 32 subjects of both sexes performed the Go/NoGo and Stop-signal tasks. The Go/NoGo task: green or red stimuli were presented alternately to the left or right side of the butterfly image which appeared in the center of the monitor. The participants were asked to press different keys depending on the place of appearance of the green stimulus and to ignore the red stimulus. The Stop-signal task: stimuli consisted of vowel and consonant letters in green or red. The participants had to distinguish between green vowels and consonants while red letters had to be ignored. As result, the greatest activation was observed in the cerebellum. The left cerebellum was activated mainly in the Stop-signal task, both cerebellum hemispheres were activated in the Go/NoGo task. It’s known that cerebellar hemispheres are partly connected with the contralateral cerebral hemispheres. The large left cerebellum activation in the Stopsignal task may be related to the right hemisphere which associated mainly with cognitive control. The bilateral cerebellum activation in the Go/NoGo task may be related to the involvement of spatial attention. Spatial information processing may be associated with bilateral extension of the brain network of cognitive control.
The research was supported by the Russian Science Foundation (project@16-18-00066).